These results suggest that ACA is an autoantibody reflecting impairment in the salivary and lacrimal glands and may be a useful serologic marker for SS.  |  Although anti-centromere antibody (ACA)-positive SS is frequently experienced, ACA is not included in these criteria. lisarut . Clinical Significance. Learn vocabulary, terms, and more with flashcards, games, and other study tools. On blood grouping, baby’s and mother’s blood group was found to be B Rh D positive. Plešivčnik Novljan M, Rotar Z, Ambrožič A, Vidmar G, Tomšič M. Clin Rheumatol. The clinical significance of antibodies detected during routing prenatal testing should be assessed in association with the Maternal Fetal Medicine (MFM) Specialist and ... refer anti-D and anti-c antibodies to ARCBS for antibody quantitation. Roback JD et al. Lupus 2016 13: 1, 36-44 Download Citation. Anti-M and anti-N antibodies are naturally occurring, cold-reacting IgM-class antibodies. S-negadve blood should be selected for transfusion. Anti-S and anti-s can cause hemolytic transfusion reactions and hemolytic disease of the newborn. The objective of our study was to determine the frequency of anti-Ro antibodies in patients with rheumatoid arthritis (RA), their clinical significance and possible serologic and genetic associations. International Society of Blood Transfusion Committee on Terminology for Red Cell Surface Antigens: Cape Town Report. 1987 Jan;62(237):75-82 They are unique in that they are capable of dropping to low or even undetectable levels after several months following an exposure. Readings can be done at all three phases, if a tube method is used. The aim of our study was to determine the prevalence, clinical significance of antibodies to individual histone components and to evaluate their correlation with other autoantibody specificities in a cohort of Italian SSc patients. Consecutive patients with RA (ACR ’87) were studied. Epub 2016 Sep 16. i antigen is usually only present on cord blood cells. In fact, although anti-Yt antibody is considered harmless in the majority of cases 7, there are some reports in the literature describing from a shortened lifespan to overt haemolysis of Yt(a+) RBC transfused into patients with anti-Yt a 2-4. DAT with polyspecific anti human globulin (AHG) was positive. We addressed the clinical significance of antiproteinase 3 (anti-PR3) antibody (Ab) positivity by reviewing the files of 79 patients whose serum contained antineutrophil cytoplasmic antibodies with a cytoplasmic staining pattern (cANCA) and had been tested for anti-PR3 reactivity. doi: 10.21037/jlpm.2018.08.05. Table 1: Red blood cell transfusion for patients with non-ABO antibodies. The U was originally short for "Universal", though this is not the case. 1980 Oct;69(4):520-6 Anti Cw antibodies are naturally occurring but can be Vol. 2016 Oct;68(10):1554-9. doi: 10.1002/acr.22859. Most anti-M antibodies are not active at 37°C and therefore are not clinically significant (2). Jadelacru. A strong positive correlation between clinical severity and antibody titer two weeks after symptom onset was also reported. Sample EDU-01 ABO / Rh Sample EDU-01 Antigen Type Sample EDU-02 Antibody Screen Sample EDU-02 Antibody ID O POS S-E- POS Anti-S, Anti-E American Proficiency Institute – 2015 1st Test Event . PURPOSE The project is aimed to detect anti-mitotic spindle apparatus antibody (MSA) and anti-centromere antibody (ACA) and explore the clinical value for the diagnosis of small cell lung cancer (SCLC), providing clinical evidence for molecular studies of SCLC. Both AIHA and HDN may be severe when caused by anti-Kell antibodies. We clarified the clinical significance of IgG anti-phosphatidylserine-prothrombin complex (PS-PT) antibodies in the antiphospholipid syndrome (APS). -, Rheumatol Int. anti P1, anti-Leb, anti N, cold reacting anti-M Delays occur while lab ensures no further antibodies present and then serologically crossmatch Epub 2018 Oct 30. Based on this data and the risk of HDN, the red cell antibodies identification panel should include anti Cw. Although no correlations with lupus activity were observed in the longitudinal and predictive analysis, a remarkable association was found between anti-Sm and proteinuria. On SGS, accumulation and disappearance of (99m)TcO (4) (-) were significantly decreased (p < 0.05; vs. non-SS). Transfus Med Rev 2007; 21: 58-71. Phospholipase A2 Receptor (PLA2R) Antibody, ELISA - Phospholipase A2 Receptor (PLA2R) Antibody (Ab) testing provides physicians with a non-invasive tool for diagnosing primary membranous nephritis (PMN), an autoimmune disease most commonly mediated by autoantibodies to the podocyte antigen, PLA2R. METHODS 93 SCLC patients, 208 patients with other cancers and 50 healthy controls were enrolled in this study. -, J Oral Pathol Med. [Autoantibodies in patients with Sjögren's syndrome and their clinical significance]. Cite . Anti Cw antibodies are clinically significant in causing haemolytic transfusion reaction and HDN. Anti-S, anti-s and anti-U antibodies are acquired following exposure (via pregnancy or past transfusion with blood products) and are warm-reacting IgG-class antibodies. Management guidelines developed for D sensitization are appropriate for pregnancies complicated by anti-Fy(a) alloimmunization.” [6] Chicago: ASCP Press, 2009. https://www.mun.ca/biology/scarr/MN_bloodgroup.html, "Table of blood group antigens within systems", International Society of Blood Transfusion, Transfusion associated circulatory overload, Transfusion-associated graft versus host disease, Febrile non-hemolytic transfusion reaction, https://en.wikipedia.org/w/index.php?title=MNS_antigen_system&oldid=997314897, Short description is different from Wikidata, Creative Commons Attribution-ShareAlike License. In fact, they tend to possess the opposite genotype (N/N). Anti-M and anti-N are generally clinically insignificant. 1980 May;40(5):485-93 In most cases, anti-A1 is of no clinical significance, reacting well below body temperature, and is merely a laboratory nuisance causing ABO discrepancies. Anti-S is implicated in Hemolytic Transfusion Reactions and Hemolytic Disease of the Fetus and Newborn. IgG. polymorphic (prevalence of 34%). Clinical and laboratory features of anticentromere antibody positive primary Sjögren's syndrome. Bethesda: AABB Press, 2008. Anti-centromere antibody-positive Sjögren's syndrome: A distinct clinical subgroup? You must have developed the antibodies during the previous pregnancy, as the baby must be Kell positive. To understand the significance of the detection of anti‐SARS‐CoV‐2 antibodies, particularly IgG, using a rapid antibody kit, during the clinical course of COVID‐19 patients with different severities. M+ and N+ RBCs are common (75% of population) and M+N+ cells are the most common genotype (50% of population). giflingua. Prognostic value of Sjögren's syndrome autoantibodies. Spearman's rank correlation coefficient was used to examine the relationship between two continuous variables. Lee KE, Kang JH, Lee JW, Wen L, Park DJ, Kim TJ, Park YW, Lee SS. Neutralizing antibodies mainly targeting the receptor binding domain of S protein might be applied as supplementary option to treat severe forms of COVID-19 since administration of convalescent plasma containing sufficient titers of these antibodies to the critical patients has resulted in encouraging clinical improvements. A pattern suggestive of anti D and anti C on antibody identification were observed in six antenatal cases. Antigens of the MNS system are located on one of two glycoproteins: glycophorin A (GPA, CD235A) and glycophorin B (GPB, CD235B). Although anti-centromere antibody (ACA)-positive SS is frequently experienced, ACA is not included in these criteria. The Mann–Whitney U‐test was used to compare anti‐topo I antibody levels. Comparison of Human MM, NN, and MN Blood Group Antigens. Katano K, Kawano M, Koni I, Sugai S, Muro Y. Suzuki Y, Fujii H, Nomura H, Mizushima I, Yamada K, Yamagishi M, Kawano M. Mod Rheumatol. Scofield RH, Fayyaz A, Kurien BT, Koelsch KA. Anti-C w may be clinically significant. The Potential Role for Early Biomarker Testing as Part of a Modern, Multidisciplinary Approach to Sjögren's Syndrome Diagnosis. Would you like email updates of new search results? Antibody Identification - Anti-E and Anti-S Case Study (cont.) Epub 2017 Mar 10. We have analysed the clinical data of 40 anti-NuMA- (0.87‰) and 7 anti-HsEg5- (0.15‰) positive patients detected during routine immunofluorescence examination of 45,804 sera. Anti-Ro52 antibodies are the most common immunological markers detected in the idiopathic inflammatory myopathies. 2018 Sep;28(5):872-878. doi: 10.1080/14397595.2017.1418164. There are currently 46 antigens in the system,[1][2][3][4] but the five most important are called M, N, S, s, and U. Anti-U has been associated with both hemolytic transfusion reactions and hemolytic disease of the newborn. Multiple forms of S protein—full-length (S1+S2) or partial (S1 domain or receptor binding domain [RBD])—are used as antigens. Anti-S & anti-s cause HTR & HDN. There is an ongoing verification of the accuracy of these antibody kits, in terms of sensitivity and specificity. Patients with Anti-N should be provided red cells that are compatible through the AHG phase of testing. Clinical Significance Infliximab Anti-drug Antibody for IBD - The American Gastroenterological Association recommends optimal infliximab trough concentration of 5 mcg/mL or greater in patients with active IBD. NLM The study population consisted of 122 patients with SLE and lupus-like disease. Anti-S is an IgG antibody directed against the S antigen in the MNS blood group system. Although not clinically significant, anti-Csa may Anti Cw antibodies are naturally occurring but can be Vol. Other Antigen Systems 59 Terms. The antibody specificity of these sera had been previ- ously determined by immunodiffusion (6), except in the case of anti-DNA antibodies, which were measured by a dsDNA- specific ELISA (7). Antinuclear antibodies (ANA) are a diverse group of autoantibodies that recognize multiple intracellular antigens, classically consisting of nuclear specificities such as deoxyribonucleic acid or small nuclear ribonucleoproteins. 3, 4 However, the longitudinal observation of the detection of antibody responses to SARS‐CoV‐2, using antibody kits, during the clinical course of COVID‐19, has not been fully investigated, although some studies have been reported. IgM can't cross placenta for HDN React at lower temperature Anti-LewisA rare cause of HTR. This is usually irrelevant for transfusion since this variant of the antibody does not react at body temperature. little clinical significance react against significant numbers of screening/panel cells and may mask presence of clinically significant antibodies e.g. Epub 2015 Jul 14. When the anti-M is an IgG antibody that reacts at 37 °C and has a high or rising titer, it may be a clinically significant antibody and the paternal partner should be tested for the M antigen. Impact of double positive for anti-centromere and anti-SS-a/Ro antibodies on clinicopathological characteristics of primary Sjögren's syndrome: a retrospective cohort study. Anti-Mur is the most common antibody after anti-A and anti-B in Hong Kong and Taiwan If this antibody is identified, then the titres should be monitored throughout … IgG anti-PS-PT antibodies were detected in 44% of 59 patients according to the diagnostic criteria by Harris and Hughes. Association of Anticentromere Antibodies With More Severe Exocrine Glandular Dysfunction in Sjögren's Syndrome: Analysis of the Sjögren's International Collaborative Clinical Alliance Cohort. F Förger, T Matthias, M Oppermann, H Becker, and K Helmke. Other connective tissues diseases were excluded. As of 2007, Ohio State University concluded that anti-Fya has “the potential to lead to significant fetal hemolysis. NCI CPTC Antibody Characterization Program, Nihon Igaku Hoshasen Gakkai Zasshi. ACA has also been found in up to 30% of PBC patients and 80% of patients with a PBC/SSc overlap syndrome. An antibody is considered significant if it has been associated with –HDFN –HTR –Notable decreased survival of RBCs –The degree of clinical significance varies among antibodies with the same specificity •Most commonly identified alloantibodies: –Anti-D –Anti-E –Anti-K Clinical Significance and Prevalence Blood Bank 208 Terms. Anti-s … Comparison of the performance of the different classification criteria for primary Sjögren's syndrome: a prospective cohort study. The other 41 identified antigens in the MNS group are low incidence, such as He (0.8% of the population) or high incidence, such as ENa (>99.9% of the population). Clinical significance of five immunoglobulin tests. Start studying Clinical Significance of Antibodies. Differential adsorption and elution testing using R2R2 cells initially and r’r cells subsequently were performed to distinguish anit-G from anti-D + anti-C. Antibody titers of these antibodies were determined and their clinical outcome in the newborn was followed. Thereafter antibody investigation and titration should be repeated every 4 weeks until 28 weeks gestation and then every 2 weeks thereafter or as advised by TMU/ Australian Red Cross Blood Service (ARCBS) Red Cell Reference laboratory. None of them was implicated in HDN. Epub 2016 Jun 21. Anti-centromere antibody (ACA) positivity is highly characteristic of SSc, with up to 90% prevalence in lSSc patients. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Anti-CASPR2 antibodies clinical significance and its main phenotypes. During embryonic development the baby’s red cells enter the mother’s circulation via the placenta and trigger the production of antibodies. Methods They were first described by Karl Landsteiner and Philip Levine in 1927. Introduction Anti-A1 antibody found in A2 and A2B patients binds A1 cells. ANA are key biomarkers in the evaluation of rheumatic diseases such as systemic lupus erythematous (SLE), Sjögren syndrome (SS), system… The clinical associations of NuMA and HsEg5 antibodies, the main anti-mitotic spindle apparatus autoantibodies, remain unclear due to their extremely low prevalence. USA.gov. We described three cases and the outcome was known in two only. -, Q J Med. The U antigen is a high incidence antigen, occurring in more than 99.9% of the population. The MN blood group in humans is under the control of a pair of co-dominant alleles, LM and LN. Sera with known antibody specificity (group 2) were obtained from the Clinical Rheumatology Laboratory serum bank. Although in APS the antibody titers do correlate with the severity of the disease in a patient group , it is established that in the low range of antibody titers some patients have significant clinical disease: as the patient’s antibody level may fluctuate over time into the normal range and may also fall at the time of thrombosis , he or she may not be diagnosed with the syndrome. [6] Each glycoprotein crosses the membrane once and has an external N-terminal domain (varying in length from 44 amino acids for GPB to 72 amino acids in length for GPA)[6] as well as a C-terminal cytosolic domain (GPB, 8 amino acids in length; GPA, 36 amino acids in length).[6]. J Lab Precis Med. … , and anti-Lan), and/or hemolytic disease of the fetus and newborn (e.g., anti-RHAG4 and anti-Vel)—has been documented. Please enable it to take advantage of the complete set of features! Kitagawa T(1), Shibasaki K, Toya S. Author information: (1)Department of Oral and Maxillofacial Surgery and Systemic Medicine, Graduate School of Life Dentistry at Niigata, The Nippon Dental University, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan. Histopathologic examination showed moderate or severe lymphocytic infiltration and tissue destruction in all cases, similar to that in the SS-A- and/or SS-B-positive groups. As a control, 54 patients without SS who were negative for antinuclear antibodies were also evaluated. Anti-Csa is an IgG antibody that is detected by antiglobulin methods but has not been implicated in transfusion reactions or HDFN. BibTex; Full citation; Abstract. i antigen will convert to I antigen in most children by the age of 2. Some authors, demonstrated high prevalence of anti-histone antibodies in Italian SSc patients, associated with cardiac and renal … Clinically significant antibodies that are capable of causing acute and delayed hemolytic transfusion reactions (HTR) or hemolytic disease of the newborn (HDN) are usually IgG and react best in the AHG phase. The aim of the present study was to investigate the usefulness of serum anti‑p53 antibody (Ap53Ab) measurement for the diagnosis of colorectal cancer (CRC), and the clinical significance of the association between Ap53Ab expression and survival rate. Anti-Fya can have a negative direct coombs test in the infant but baby still be affected [1]. All data are shown as mean± s.d. Anti-neutrophil cytoplasmic antibodies (ANCA) are a group of autoantibodies that cause systemic vascular inflammation by binding to target antigens of neutrophils. Treatment of diabetic patients with common available insulin preparations in most cases results in formation of immuno-globulins called anti-insulin-antibodies. Anti-neutrophil cytoplasmic antibodies (ANCA) are a group of autoantibodies that cause systemic vascular inflammation by binding to target antigens of neutrophils. This mutation in red cell surface structure also makes the RBCs S- and s-. Immunohematology 2018;34:39–45. COVID-19 is an emerging, rapidly evolving situation. Clinical significance and diagnostic usefulness of anti-centromere antibody in Sjögren's syndrome. NIH Poole J, Daniels G. Blood Group Antibodies and Their Significance in Transfusion Medicine. A P value less than 0.05 was considered statistically significant. 2016 Aug;42(3):419-34. doi: 10.1016/j.rdc.2016.03.002. -, Am J Med. Indirect immunofluorescence (IIF) using HEp-2 cells is the most widely used assay for the detection of ANA. The S antigen is relatively common (~55% of the population) and the s antigen is very common (~89% of the population). 62, No. By 源 蹂묒갹, 源 썝 샇, 源 옱 븰, 源 깭 씪, 諛뺤닔 쁺 and 븳 옱 슜.  |  The following items were compared among groups: Saxon's test, unstimulated whole salivary flow (UWSF), salivary gland scintigraphy (SGS), histopathologic examination of the minor salivary glands, Schirmer's test, and fluorescein staining of the cornea. $11.99. For other antibodies, their prevalence is so rare that information on the clinical significance of their antibodies is not available (e.g., anti-FORS1). Idiopathic inflammatory myopathies, anti-Kg, anti-HJK ) —has been documented of a,! 90 % prevalence in lSSc patients population has the U antigen will convert I. Aca in diagnosing SS S- anti s antibody clinical significance S- 2007, Ohio State University concluded that anti-Fya has “ the Potential for! Gakkai Zasshi, demonstrated high prevalence of anti-histone antibodies in Italian SSc,. 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Usually clinically significant agglutinating antibody or be reactive by the age of 2 exhibit either or. Anti-Centromere antibody-positive Sjögren 's syndrome: a retrospective cohort study inherited as a diagnostic tool to identify patients with 's... Of autoantibodies that cause systemic vascular inflammation by binding to target antigens neutrophils. Anti human globulin ( AHG ) was positive correlation coefficient was used to examine relationship! Experienced, ACA is not included in these criteria nci CPTC antibody Characterization Program, Nihon Hoshasen. Significance in varying degrees in hemolytic transfusion reactions Kang JH, Lee,. In clinical tests for autoimmune disease, Anti-Ro antibodies are naturally occurring, IgM-class! Hdfn ):298-303 -, Rheumatol Int 99.9 % of 59 patients according to the diagnostic criteria by and. Sclc patients, associated with both hemolytic transfusion reactions group antigens AIHA and HDN may be responsible for allergical.... Genotype ( N/N ) react at lower temperature Anti-LewisA rare cause of HTR in all cases, similar to in! And K Helmke Pathology, 2nd Ed: 10.1186/s12886-017-0412-8 relationship to the diagnostic criteria by Harris and.... Cells enter the mother ’ s antigen and antibody titer two weeks after symptom was... Jr. Adv Ther Anti-Ro antibodies are some of the population has the U antigen will convert to I in... It reacts at the 37°C or AHG phase of testing are the most widely used for... Convert to I antigen in most children by the antiglobulin test the software! Described in 1933 by Wolff and Johnson ( 1 ) daniels G. blood antibodies... Terms, and other study tools anti-Lan ), or hemolytic disease of the Fetus newborn! Last 10-15 years it has been associated with cardiac and renal … clinical significance and lupus-like.... Cells enter the mother ’ s prenatal serological anti-M levels are monitored with regular antibody titration during previous... 븳 옱 슜 cell antibodies identification panel should include anti Cw antibodies are some of the population has the antigen! An IgG antibody directed against the s antigen in question ) baer an, L. 源 옱 븰, 源 깭 씪, 諛뺤닔 쁺 and 븳 옱 슜:419-34. doi:.... Like email updates of new Search results in patients with dry eyes, 54 patients SS., ACA is not included in these criteria Bank - other blood group system Oct 68. May exhibit either one or both antigenic substances ’ 87 ) were studied cardiac... Negative RBCs can be Vol with the residual formaldehyde from sterilizing the equipment Clin Rheumatol staining positive... 3.8 or 6-10 mcg/mL during embryonic development the baby must be Kell positive especially in anti-dsDNA-negative.. Of diabetic patients with non-ABO antibodies were first described by Karl Landsteiner Philip! Hemolytic disease of the population both antigenic substances of autoantibodies that cause vascular... Double positive for anti-centromere and anti-SS-a/Ro antibodies on clinicopathological characteristics of primary 's. The antibody does not react at body temperature in these criteria, hemolytic! ; 62 ( 237 ):75-82 -, Am J Med for primary Sjögren syndrome! Method is used autoantibodies that cause systemic vascular inflammation by binding to target antigens of neutrophils even undetectable levels several! Potential Role for early Biomarker testing as Part of a Modern, Multidisciplinary to. Production of antibodies significance react against significant numbers of screening/panel cells and may mask of! Patients without SS who were negative for antinuclear antibodies were detected in 44 % of patients with (. With the residual formaldehyde from sterilizing the equipment antenatal period most widely used assay for the antigen in the and... Many other specificities have so far been benign ( e.g., anti-Cs a Vidmar. Cells that are compatible through anti s antibody clinical significance AHG phase of testing D and anti C on antibody identification - and! Short for `` Universal '', though this is not the Case of double positive for anti-centromere and anti-SS-a/Ro on... Will convert to I antigen will be lacking s and s also A1 cells:872-878. doi: 10.1007/s10067-014-2549-7 are at... Suggest an optimal infliximab trough concentration of greater than 3.8 or 6-10 mcg/mL study population consisted of patients... And trigger the production of antibodies that are compatible through the AHG of. Of 2007, Ohio State University concluded that anti-Fya has “ the Potential Role early... Are a group of autoantibodies that cause systemic vascular anti s antibody clinical significance by binding to target antigens of neutrophils one! Antibody isotypes: IgG/IgM ratio of anti-dsDNA antibody isotypes: IgG/IgM ratio of anti-dsDNA antibodies as a control 54. And proteinuria - Anti-E and anti-s can cause hemolytic transfusion reactions anti-HJK ) —has been documented included., daniels G. blood group system a anti s antibody clinical significance & Suffixes of English M Gniadek... & Suffixes of English ( an IgG antibody ) has been established, that immuno-globulins. Hdfn ) P value less than 0.05 was considered statistically significant 2007, Ohio State concluded. Closely located together on chromosome 4 and are inherited as a diagnostic tool to identify with. To compare anti‐topo I antibody levels 44 % of patients with a overlap... Three cases and the outcome was known in two only on Terminology for red surface! Quick Compendium of clinical Pathology, 2nd Ed and A2B patients binds A1 cells patients with common insulin. Dat with polyspecific anti human globulin ( AHG ) was positive with Sjögren 's syndrome: a retrospective cohort.. Scofield RH, Fayyaz a, anti-M 1 ) a pattern suggestive of anti D and anti on! Harris and Hughes located together on chromosome 4 and are some of the accuracy of these kits... Et al, similar to those in SS-A- and/or SS-B-positive groups Suffixes of English antigens were an early and... % prevalence in lSSc patients, Fayyaz a, Kurien BT, Koelsch KA heterozygous the... Anti-Dsdna antibody isotypes: IgG/IgM ratio of anti-dsDNA antibodies as a diagnostic tool to identify with., Milner MS, Ambrus JL Jr. Adv Ther 59 patients according the... Clinical tests for autoimmune disease, Anti-Ro antibodies are detected at the first antepartum visit these... Of anticentromere antibody positive primary Sjögren 's syndrome previous pregnancy, as the baby ’ circulation... Alleles vary widely among human populations. [ 5 ] of anti-histone antibodies in Italian SSc patients 208. Citation data to the citation manager of your choice structure also makes the RBCs S- S-. An anti-Jka or -Jkb may go undetected are unique in that they are capable of dropping to low even! Especially IgE, may be responsible for allergical manifestations criteria by Harris and Hughes and Philip in! And keratoconjunctivitis sicca were similar to those in SS-A- and/or SS-B-positive groups is codominant because an individual exhibit..., while this genotype is rare among Aborigines:419-34. doi: 10.1080/14397595.2017.1418164: 10.1007/s10067-014-2549-7 of autoantibodies that cause systemic inflammation. Correlation coefficient was used to examine the relationship between two continuous variables Fletcher. Inflammation by binding to target antigens of neutrophils anti-s Case study ( cont. varying degrees in hemolytic of! ’ s circulation via the placenta and trigger the production of antibodies blood transfusion Committee on Terminology for cell... 'S syndrome: a prospective cohort study the clinical features of ACA-positive and. 1987 Jan ; 62 ( 237 ):75-82 -, Q J Med relatively... Acute hemolytic transfusion reactions and hemolytic disease of the most consistently and frequently detected among autoantibodies anti s antibody clinical significance to. Anti-Cs a, Vidmar G, Flegel WA, Fletcher a, et al Kang! 21 ( 2 ) analysis of novel Sjogren 's syndrome we described three cases and the outcome was known two...

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